This chapter thoroughly analyzes the framework, significance, and prospective evolution of research and development (R&D) management in healthcare services. The efficacy and sustainability of healthcare systems are intrinsically connected to the proficient administration of research and development activities. The study examines the influence of innovative thinking, design-centric methodologies, continuous improvement (Kaizen), and technological breakthroughs, including artificial intelligence, on the healthcare sector. Additionally, it assesses the historical evolution of R&D activities on a worldwide scale and inside Turkey, emphasizing inter-institutional cooperation and innovation management systems. The text examines the application of essential research methodologies in healthcare, including experimental, observational, qualitative, and systematic review approaches, highlighting their practical implementations. The chapter highlights how artificial intelligence, machine learning, and big data analytics improve the accessibility, efficiency, and personalization of healthcare services. Furthermore, it examines Turkey's research and development initiatives in relation to the Health Transformation Program, digitalization, and comprehensive quality management. The results indicate that healthcare research and development not only propels scientific advancement but also fosters economic growth, enhances social welfare, and improves patient quality of life. The chapter emphasizes that sustainable R&D initiatives, bolstered by robust leadership, effective change management, and interdisciplinary collaboration, will be pivotal in defining future healthcare systems.