In the 21st century, the effect of globalization has increased competition among countries. Along with this increasing competition, the concept of technology has become more important for nations. For countries, high-technology products and effectiveness in value-added imports and exports are among the significant factors for the sustainability of growth. For this reason, the determinants of high technology have become an important research topic. This study employs panel data analysis for 105 selected countries over the period 2010-2019 and selects the System-GMM method. Through this analysis, the impact of high-technology determinants on high-technology exports is measured. In the analysis, the dependent variable is high-technology exports, while the independent variables are the education index, foreign direct investments, trade openness ratio, GDP, and patent applications. As a result of the analysis, the one-period lagged value of high-technology exports, L.lnHTE, was found to be significant at the 1% level in the System GMM models. According to the one-step GMM model, there is a significant relationship at the 1% level between high-technology exports and the independent variables. According to the two-step GMM model, a statistically significant and positive relationship at the 1% level was identified between high-technology exports and the education index, foreign direct investments, and trade openness variables. Furthermore, in the two-step GMM model, a statistically significant and positive relationship at the 5% level exists between high-technology exports and both GDP and patent applications.