Recently, cancer is one of the significant reasons for deaths including all diseases. Although there are many different treatment options, the deaths majorly occurred due to high toxicity or drug resistance related to the cancer chemotherapeutics. There are many studies that can reduce toxicity and drug resistance using with nanotechnology approaches in drug delivery of cancer treatments. Targetable nanotechnological molecules are designed to support protect healthy tissues from high-level cytotoxic of chemotherapeutic agents by allowing the drug to penetrate inside to the tumor cell efficiently. In addition, due to these features, they prevent drug resistance by binding to specific targets in the tumor. This will help to select cancer cells more than the healthy cells preferably. In this section, a review is made about the innovative usage of nanotechnology in cancer and future perspectives. Various material types and nanoparticulation approaches will be discussed.