Pain is not limited to a physiological process; it is a multidimensional experience involving sensory, cognitive, and behavioral components, and it is a universal health problem that can negatively affect individuals' quality of life and functioning. Recent studies show that acute and chronic pain are common, especially in women and older age groups. The role of nurses in pain management encompasses accurate assessment, individualized care planning, and the effective use of pharmacological and non-pharmacological methods. Technology-based assessment methods, mobile health applications, wearable devices, and artificial intelligence-supported analysis systems enable objective monitoring of pain and enhance patient-centered care. Non-pharmacological methods support pain control through approaches such as music therapy, massage, aromatherapy, relaxation techniques, and virtual reality applications, while enhancing the effectiveness of pharmacological methods and reducing their side effects. Individualized pain management forms the basis of nursing care, taking into account the age, clinical condition, and psychosocial characteristics of patients, ensuring effective pain control, improved quality of life, and accelerated recovery.