Artificial intelligence (AI) is rapidly reshaping the organizational, instructional, and administrative dynamics of K–12 schools. While AI-enabled tools increasingly support decision-making, assessment, student monitoring, and resource management, their effective use depends largely on the leadership capacity of school principals. Despite the growing interest in AI in education, there remains a significant gap in practice-oriented frameworks that describe how school leaders can develop the competencies, professional cultures, and organizational structures required to guide AI integration responsibly. This chapter proposes a practice-oriented professional development roadmap for principals leading AI-integrated schools. Drawing on recent scholarship in human-centered and ethical AI, distributed and adaptive leadership, and organizational learning, the chapter conceptualizes AI not as a technical intervention but as a socio-technical transformation that influences relationships, responsibilities, and power structures in schooling. The roadmap is structured around three interconnected layers. The Foundation Layer focuses on digital infrastructure, data governance, and readiness conditions. The Leadership Practice Layer outlines how principals can integrate AI tools into instructional leadership, formative assessment, and student support while fostering teacher agency through workshops, coaching, and Professional Learning Communities. The Future Readiness Layer emphasizes strategic foresight, innovation culture, digital equity, and the development of human–AI collaboration competencies. The chapter also discusses key implementation challenges—including resource inequalities, ethical tensions, and trust issues—and provides practical tools such as planning templates, reflective questions, and illustrative scenarios. By offering a coherent and ethically grounded roadmap, this chapter contributes to emerging global discussions on AI and educational leadership, supporting principals in building resilient, responsible, and human-centered AI-integrated school environments.