This chapter examines the organizational transformation that emerges from the transition between generative artificial intelligence and autonomous agent-based systems. The discussion introduces the structural differences between content-producing models and systems capable of independent reasoning, tool execution, and long-term decision-making. It evaluates how enterprises can deploy agentic architectures through a staged roadmap that begins with data readiness, expands through operational scaling, and matures into composable and adaptive business environments. The chapter explores the implications of autonomous agents for labor dynamics, including the shift of human work from execution toward oversight and strategic orchestration. Attention is directed toward governance, cybersecurity, and ethical considerations which shape the responsible use of autonomous entities in business operations. The analysis emphasizes that enterprise value depends on data quality, organizational trust, and governance maturity rather than model selection. The chapter provides executives and researchers with a framework that supports strategic planning for agent adoption and guides organizations toward resilient and intelligence-driven operating structures.