Today, poor academic performance is among the main concerns of teachers, curriculum developers and stakeholders in the entire education sector. Because low academic performance may negatively affect students' active participation in future national developments, their access to higher education institutions, and their ability to find employment in the highly competitive job market. It is very important to share information with the stakeholders involved in the determination of education policies in order to identify the factors that contribute positively to the academic performance of the students and to start the process of struggling quickly. Therefore, the main purpose of this study is to examine the effects of teacher-student relationship on students' academic performance. Relational screening model was used in the study. The study group of the research consisted of a total of 159 students studying in the last year of high schools in a town with a population of approximately eighty thousand in a city in the Eastern Anatolia Region. The data of the study were collected with the help of a questionnaire. The data obtained in the study were transferred to the computer using the SPSS package program, and the average and standard deviation values were calculated and evaluated. As a result of the analysis of the data; In the study, it was observed that there was a significant relationship between the teacher-student relationship and the academic performance of the students. In addition, it was determined that the factors affecting the intimate relationship between teacher-student and students' academic performance depend on the level of communication between students and teachers, which plays a critical role. Some suggestions were presented in line with the findings of the study.