In dentistry, regenerative therapy involves the regulation and regeneration of oral tissues that have changed as a result of disease or trauma. The complex anatomy, which originates from various tissues and includes mineralized tissues such as cementum, dentin, and bone, also contains various cell populations. The use of various biomaterials for the regeneration of these cell populations has been tested in the past. These include barrier membranes, morphogenetic proteins, and various human/animal/synthetic bone grafting materials. Some researchers have abandoned the use of these materials altogether and suggested the use of three-dimensional scaffolds obtained from the patient's peripheral blood. Thus, plasmas containing anticoagulants and then fibrin without anticoagulants were used as scaffolding. Platelets provide coagulation during bleeding and prevent blood loss. Due to their easy availability and the growth factors they contain, platelets have gained popularity in many medical practices and regenerative therapy in dentistry. Periodontology, oral and maxillofacial surgery, endodontics, and pediatric dentistry constitute the main areas of use of PRF in dentistry. One of its main uses in periodontology is regenerating periodontal intrabony defects. Its main areas of surgery include placement in extraction sockets, sinus augmentation, filling of the operation area following tumor removal, and use in osteomyelitis infections. The main use of PRF in endodontics is in regenerative procedures. PRF is very simple to prepare as it does not require activation by additional factors such as bovine thrombin and extrinsic anticoagulants, and the preparation time and preparation cost are significantly low. There are no restrictions on the use of PRF in patients who are diabetic, use anticoagulants, have malignant tumors, use bisphosphonates, or smoke. It is stated that PRF increases regeneration capacity, regulates bone size and contours, and reduces infection. When ease of use, low cost, and autologous character are combined; It becomes an ideal biomaterial worthy of further investigation in various procedures in dentistry.