This review focuses on the adsorption of protein basically, and Bovine Serum Albumin (BSA) in particular. Protein adsorption in materials used as biomaterials is an appreciable issue regarding material biocompatibility. Additionally, since BSA is a model protein used for biomedical purposes, its adsorption was examined and compared by obtaining information from different international and national articles. In the search, initially, general information was given about BSA chosen as a model protein in experimental articles and then about the most used adsorption isotherm models and adsorbent materials. Then, some of the BSA adsorption studies were examined comparatively. Literature and master theses using different surfaces, including metal, polymer and nanoparticle-based materials, have been read to study adsorption behaviour. In this context, changes in the maximum adsorption level in BSA adsorption experiments depending on the surface hydrophobicity of the material, surface charge and surface roughness are explained. The results were compared considering the effects of experimental conditions such as BSA concentration, pH, temperature and contact time on the adsorption process. Recently, in the study, the maximum adsorption capacities of several adsorbent materials obtained from the literature are presented in a comparative table.

In general, this study aims to contribute to the understanding of BSA adsorption and its relationship with surface properties and environmental factors through a literature review. In addition, it is a review that aims to provide valuable information for the development and optimization of biomaterials for various biomedical and biotechnological applications. Another aim of the study is to motivate further research to explore the potential of BSA adsorption in the design of advanced biosensors, drug delivery systems, and tissue engineering scaffolds. In addition, a compilation containing general information about BSA and adsorption concepts will contribute to Turkish references in this field.