This book chapter comprehensively addresses multidisciplinary treatment approaches between orthodontics and oral, dental, and maxillofacial surgery. In individuals with cleft lip and palate, orthodontic treatment before, during, and after the surgical process constitutes one of the cornerstones of treatment success when correcting skeletal jaw anomalies surgically. Additionally, the integration of impacted teeth into the oral cavity is only possible through coordinated planning of surgical exposure and orthodontic traction. In cases of severe maxillofacial deficiencies, gradual expansion of the jawbones is achieved through distraction osteogenesis; in this process, orthodontic treatment plays a critical role in ensuring harmony at both skeletal and dental levels. When these approaches are combined with individualized planning, interdisciplinary collaboration, and accurate timing, it becomes possible to achieve both functional and aesthetic success.