Multidisciplinary approaches in dentistry are essential for achieving optimal results. The collaboration between orthodontics and prosthodontics is particularly crucial in advanced and difficult cases. In this context, the cooperation of these fields ensures optimum aesthetics and function in cases such as tooth deficiencies, malocclusions, loss of vertical dimension, excessive tooth wear, and overturned molars. Achieving the ideal tooth position prosthetically in difficult cases, such as overturned, malposed, or crowded teeth, is only possible with an orthodontic intervention performed beforehand. Nowadays, orthodontics and prosthetics cooperation has become digital thanks to advanced digital dentistry. Contemporary approaches such as digital planning, CAD/CAM technology, clear aligners, and piezocision make the treatment process more predictable and patient-oriented. This method facilitates the establishment of interdisciplinary relationships and actively involves the patient in the treatment process. Consequently, for effective treatment, it is essential that the orthodontist and prosthodontist together devise a strategy, coordinate patient follow-up, and involve the patient in the treatment process.