Nowadays, the burden of cancer is rising, particularly in developing and developed nations (1). One of the first five cancers that cause the death of women worldwide right after lung cancer is breast cancer (1). Cell transduction is a critical stage in the formation and growth of cancer (2). Many signaling pathways that promote tumor growth, invasion, and metastatic capabilities have been found in breast cancer, as they have been in other cancer types. Cyclin-dependent kinases, Notch, NF-kB, PI3K, JAK/STAT, Hedgehog, Hippo, TGF-β, Wnt/ β-catenin, PARPP are among the signaling pathways related to breast cancer (1). In this review, the importance of focusing on key signaling pathways targeted in the treatment of breast cancer is explained in detail. We hope that the information in this publication will help guide preclinical and clinical research in the creation of effective drugs and improve the treatment of breast cancer patients with further studies in this area.