Considered as the ‘Heartland of the World’ by Mackinder, Central Asia has an essential influence on the power dynamics of the world. With the advantage of the revitalisation of the ancient Silk Road, Russia, United States of America, European Union, China and Turkey have different outcomes with their policy implications on the framework of complex interdependency. Due to the different bargaining powers, vulnerabilities and purposes of the states, each power has focused on the region in a different way. So, this paper aims to analyse the power dynamics on the region via revitalisation of the Silk Road on the concept of complex interdependency. Within the selected articles and journals, literature reviews for the theoretical framework and policy papers for the policy implications is used to deepen the analysis. To do so, the complex interdependency model will be analysed under three different aspects to explain its policy implications on the region, such as economic dimension, energy security section and human rights and democratization issues.