Many studies have been carried out on Sirtuin (SIRT) proteins, with their molecular structure and the metabolic pathways they participate in, under the titles of many diseases and health-related studies from cancer to diabetes. It is a member of the signal protein family that has a role in metabolic regulation. Studies have shown that the protein structure has a highly conserved structure. Sirtuins; It is a structure belonging to the NAD-dependent lysine deacetylase protein class, which has a biochemical role in various cellular processes such as metabolism, transcription and DNA repair, and is involved in many biological events. There are seven mammalian homologues, named SIRT1 through SIRT7. Studies show that seven members of the SIRT family play vital roles in health and disease conditions. In particular, all SIRTs share a nicotine adenine dinucleotide (NAD) binding catalytic site and can act specifically on different substrates depending on the biological processes in which they are involved. From in vitro studies, sirtuins have been shown to be involved in aging, transcription, apoptosis, inflammation and ıt has been associated with influencing cellular processes such as stress resistance, as well as energy efficiency in low-calorie situations.