Gamification has been proposed as a novel methodology for reducing stress, anxiety and negative emotions experienced by children. Gamification-based applications are implemented through various digital tools, including web and mobile applications, virtual reality technologies, digital storytelling and wearable devices. These tools have the potential to enhance children's hospital experiences by increasing their cooperation, especially during interventional procedures.. The utilisation of gamification-based applications has been demonstrated to be an effective method of mitigating anxiety and stress in children undergoing highly stressful medical procedures. However, the unregulated use of these technologies may lead to several risks, including screen addiction, social isolation, and a sedentary lifestyle. Consequently, it is imperative to simultaneously develop strategies to mitigate potential adverse effects while designing gamification applications. Pediatric nurses play an important role in improving the quality of care by closely following technological developments in this field, ensuring that gamification-based interventions are implemented in an effective, ethical and safe mannerIn this chapter, anxiety and stress in children are examined in relation to the concept of gamification. Innovative interventions based on gamification and focused on reducing anxiety and stress were discussed.