Global economic developments bring along significant uncertainty factors that directly affect the macroeconomic stability of countries. In this context, the Economic Policy Uncertainty Index (GEPU) has been widely used in recent years to analyze the causes of economic fluctuations. This study analyses the bidirectional causality relationship between the Global Economic Policy Uncertainty (GEPU) index and economic stability in Turkey from 1997 to 2023. Using time series methods, the Toda-Yamamoto causality test results reveal a bidirectional causality between GEPU and GDP. Additionally, unidirectional causality runs from GEPU to inflation and from GEPU to the exchange rate. Variance decomposition findings show that changes in GEPU are primarily explained by interest rates, followed by GDP, inflation, and exchange rates. This highlights that economic uncertainty is mainly influenced by interest rates and, therefore, by monetary policy. The results suggest that ensuring predictable and stable monetary policies is crucial for reducing the negative effects of global economic policy uncertainty on the domestic economy.