Biomaterials Signal Pathway Modulation: From Cellular Mechanisms to Therapeutic Applications
Chapter from the book:
Karakurt,
P.
&
Fırat,
M.
(eds.)
2025.
Current Approaches in The Field of Health.
Synopsis
Cellular signaling pathways form the biochemical basis for fundamental biological processes such as homeostasis, growth, and differentiation in multicellular organisms. Conversely, the dysregulation of these pathways plays a key role in the development of many pathologies, including cancer and inflammatory diseases. This chapter addresses the transformative potential of biomaterials in targeting these critical signaling cascades.
Nanoparticles, exosomes, and stimuli-responsive systems are utilized to protect therapeutic agents and specifically direct them to diseased tissue, thereby both reducing systemic toxicity and enhancing drug efficacy. In biomaterial design, factors such as mechanotransduction, biocompatibility, and surface modification are critical elements that guide cell fate decisions.
Future perspectives are focused on intelligent platforms like Lab-on-Chip (LoC) systems, sensor-integrated implants, and personalized 3D/4D bioprinting technologies. These innovative systems enable feedback-controlled drug release that responds to local biomarker concentrations. Signal-guided biomaterial engineering is playing a critical role in developing individualized, precise, and effective treatment strategies against biochemical abnormalities.
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Copyright (c) 2025 Papatya Karakurt- Meryem Fırat; Amine Nur Arıkan- Ayçin Köycekaş- Yahya Ateşpolat- Müdriye Yıldız Bıçakçı- Arif Caner Erdoğan- Bilgenur Karaçor- Mehmet Elmalı- Bürke Çırçırlı- Mert Can Emre- Cihan Adanaş- Sezai Özkan- Elem Kocaçal- Ertuğrul Sarı- İlyas Ün- Esra Kuran- Eren Canbolat- Mahir Coşkun- Azad Duman- Merve Kandazoğlu Erdem- Betül Karabudak- Simge Erdal- Meryem Fırat- Burcu Demir Gökmen- Mine Cengiz- Naime Çelik- Rauf Melekoğlu- Ayse Sebnem Erenler- Sanem Can Sarıoğlu- Esra Buğra- Deniz Uğur Cengiz- Selen Özdemir- Şeyda Yetginler Memiş- Ümit Topcuoğlu- Yasin Özden- Zehra Güveren- Gül Bülbül Maraş- Ahmet Utuş