Cleaning agents and cosmetic products are widely used consumer commodities, associated with continuous and heterogeneous human exposure in diverse settings. Ensuring their safety requires a comprehensive approach that integrates formulation design, raw material qualification, Good Manufacturing Practices (GMP), physicochemical and microbiological quality control, stability testing, and accurate labeling. In Türkiye, cosmetic products are regulated under the Cosmetic Products Regulation, which is fully harmonized with European Union Regulation (EC) No. 1223/2009. This regulatory framework establishes core obligations, including pre-market notification and maintenance of a Product Information File (PIF). In contrast, household cleaning products follow distinct regulatory pathways depending on their intended use. Products with biocidal claims (e.g., disinfectants) require authorization under the Biocidal Products Regulation. This chapter provides a structured, evidence-based overview of GMP-driven manufacturing, critical safety and performance testing strategies, key human health endpoints—particularly dermal sensitization and respiratory effects—and ethical aspects of production, including non-animal testing approaches, transparency, and sustainability.