Today, the increasing popularity of sports and various health-related concerns have led to a rise in the number of sports injuries. Although there are many intrinsic and extrinsic factors that can be effective on sports injuries, genetics may be a significant biological marker for non-contact soft tissue injuries. In the literature, the hereditary mechanism of these injuries has been explained through certain specific gene variants; however, the characteristics of different genes have not been sufficiently investigated. The present study was conducted to examine current research within the scope of the literature regarding the relationship between genetics and non-contact soft tissue injuries in sports, specifically focusing on the GDF5 gene. In the study, PubMed and PubMed-Central search engines within the NCBI database were examined in detail. Data obtained by entering the keywords 'relationship between sports and genetics,' 'non-contact soft tissue injuries in sports,' and 'GDF5 gene and sports injuries' into the relevant search engines were evaluated. In the current study, it was determined that genetics may have a power of influence on athletic performance. For this reason, certain genes may be important regulators in non-contact soft tissue injuries. Furthermore, the GDF5 rs143383 polymorphism may affect the structural integrity of soft tissues, making both athletes and sedentary individuals susceptible to tissue sensitivity. In conclusion, the impact of genetic factors on sports performance is still in a developmental stage. More studies are needed in this field.