Spinal infection constitutes a challenging diagnostic and treatment issue that requires a multidisciplinary approach involving spine surgeons, radiologists, and infectious disease specialists. Infections are usually caused by bacterial microorganisms. Hematogenous spread of the microorganism from a distant infected area is the most common route for spinal infection. Most patients may be managed conservatively with antibiotics, bed rest, and spinal braces in early stages. Surgical treatment is required in cases of obvious or impending instability, progressive neurological deficits, failure of conservative treatment, spinal abscess formation, severe symptoms indicating sepsis, and failure of previous conservative treatment. Patients with spinal infections need to be closely monitored with several neurological examinations and imaging studies in both cases.