Intrahepatic Cholestasis
Chapter from the book: Altuner, Y. (ed.) 2025. Current Approaches to Pathological Formations Related to Obstetrics and Child in The Field of Midwifery.

Burcu Okutucu
Karabük University
Figen Gözelyüz
Karabük University
Eylül Akış
Karabük University
Sümeyra Erdoğan
Karabük University
Fateme Poormoarefi
Karabük University
Mahira Saidova
Karabük University

Synopsis

Intrahepatic cholestasis of pregnancy (ICP) is a liver disorder that arises due to impaired bile flow. It typically manifests between the 25th and 30th weeks of pregnancy, with symptoms such as itching, jaundice, digestive problems, and fatigue. Elevated levels of estrogen and progesterone, genetic predisposition, a history of cholestasis in previous pregnancies, multiple pregnancies, certain underlying diseases, and maternal age can increase the risk. Diagnosis involves blood tests, liver function tests, and ultrasound imaging. Treatment focuses on alleviating symptoms with medications such as ursodeoxycholic acid, correcting deficiencies with vitamin supplementation, and regular medical monitoring of the fetus. In severe cases, early delivery may be recommended.

How to cite this book

Okutucu, B. & Gözelyüz, F. & Akış, E. & Erdoğan, S. & Poormoarefi, F. & Saidova, M. (2025). Intrahepatic Cholestasis. In: Altuner, Y. (ed.), Current Approaches to Pathological Formations Related to Obstetrics and Child in The Field of Midwifery. Özgür Publications. DOI: https://doi.org/10.58830/ozgur.pub795.c3371

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Published

July 4, 2025

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