
Intrahepatic Cholestasis
Chapter from the book:
Altuner,
Y.
(ed.)
2025.
Current Approaches to Pathological Formations Related to Obstetrics and Child in The Field of Midwifery.
Synopsis
Intrahepatic cholestasis of pregnancy (ICP) is a liver disorder that arises due to impaired bile flow. It typically manifests between the 25th and 30th weeks of pregnancy, with symptoms such as itching, jaundice, digestive problems, and fatigue. Elevated levels of estrogen and progesterone, genetic predisposition, a history of cholestasis in previous pregnancies, multiple pregnancies, certain underlying diseases, and maternal age can increase the risk. Diagnosis involves blood tests, liver function tests, and ultrasound imaging. Treatment focuses on alleviating symptoms with medications such as ursodeoxycholic acid, correcting deficiencies with vitamin supplementation, and regular medical monitoring of the fetus. In severe cases, early delivery may be recommended.