Weeds, owing to their high adaptability to variable and frequently changing environmental conditions, pose significant pressures on agricultural production areas and ecosystems, posing one of the most significant challenges facing global agriculture. While weed adaptation has traditionally been thought to depend on genetic diversity and rapid reproductive capacity, epigenetic mechanisms play a critical role in shaping weed resistance. Epigenetic processes, including DNA methylation, histone modifications, and small RNA-mediated editing, enable plants to respond quickly and flexibly to environmental stressors by allowing heritable changes in gene expression without altering the DNA sequence. These processes are increasingly recognized as central to the phenomenon of stress memory, where prior exposure to stressors such as herbicide application, drought, salinity, or nutrient deficiencies prime weeds for stronger responses in subsequent encounters. A particularly important aspect of epigenetic regulation is the capacity for transgenerational inheritance. Some stress-induced epigenetic modifications can be passed on to offspring, providing a hereditary "memory" of environmental conditions and conferring adaptive advantages across generations. This mode of inheritance accelerates weed adaptation by overcoming the slow pace of genetic mutation and natural selection. In agricultural ecosystems, this may explain the rapid emergence of herbicide resistance, the persistence of weeds under abiotic stress, and the ability of invasive species to establish in new habitats. Understanding epigenetic stress memory in weeds not only reshapes traditional weed adaptation models but also guides weed management strategies. Pre-treatment with epigenetic memory suggests that repeated agricultural practices may inadvertently strengthen weed resistance by selecting populations pre-adapted to future stress. Consequently, the application of epigenetic perspectives in weed research can advance sustainable control by utilizing biomarkers to monitor adaptation and by adapting agronomic practices that counteract stress memory mechanisms. By placing epigenetic plasticity at the forefront of weed biology, this perspective highlights the need for a paradigm shift in both research and management, and the recognition of weeds as highly dynamic organisms equipped with heritable epigenetic survival tools.