Sports injuries, which are defined as sports-specific injuries, have been significantly affected by the increasing popularity of sports and the continuous development of athletes. The knee joint, which is the largest and most complex joint of the human body, is one of the seven major joints of the body, where soft tissues such as the meniscus, femoral cartilage, tibial plateau cartilage, ligament and tendons are located. This complex joint is very susceptible to injuries due to its ability to withstand anatomical and physiological loads. Anterior Cruciate Ligament, an important component of the knee joint, has a key role in stabilizing the knee joint and in large mechanical loads. However, in some cases, sudden movements, strains, and rotations can cause serious damage to the Anterior Cruciate Ligament. The aim of this study is to examine the factors that cause Anterior Cruciate Ligament Injuries in detail from many perspectives. In the study, data related to Anterior Cruciate Ligament and Anterior Cruciate Ligament Injuries were determined by scanning the NCBI database. The data obtained as a result of the screening were included in the scope of the study. When the factors that may cause Anterior Cruciate Ligament Injuries are carefully evaluated, it has been determined that biomechanical and genetic factors are important risk factors in these injuries. To the best of our knowledge, the location of the Anterior Cruciate Ligament in the knee joint and the loads to which it is exposed are important biomechanical causes of injury to this region. In addition, some genes can seriously change, due to the proteins they decode, the structural integrity of soft tissues. Considering that sports have a complex structure, other factors that may cause Anterior Cruciate Ligament Injury should also be investigated meticulously.