Nuclear medicine evaluates disease at functional and molecular levels beyond purely anatomic findings by visualizing the in vivo distribution of radiopharmaceuticals. This section reviews the impact of hybrid imaging systems (SPECT/CT, PET/CT, PET/MR) and emerging detector technologies on the diagnostic workflow. In SPECT/CT, CT-based attenuation correction, iterative reconstruction (MLEM/OSEM), and resolution recovery improve contrast, reduce artifacts, shorten acquisition time, and enable low-dose protocols. On the detector side, the transition from photomultiplier tubes (PMTs) to SiPM/APD-based designs and solid-state materials such as CZT enhances energy and timing resolution, allowing rapid imaging with lower administered activity. In digital PET/CT, time-of-flight (TOF) capability and resolution gains increase the detectability of small lesions. Long axial field-of-view total-body PET and breast-dedicated positron emission mammography (PEM) offer single-bed-position imaging and higher sensitivity. For PET/MR, the limitations of MR-based attenuation correction and ongoing efforts to improve it using deep learning are discussed. The potential of AI-assisted denoising and automated segmentation to accelerate clinical workflows is emphasized. Collectively, these innovations aim to support more accessible, faster, and safer patient management. Imaging centers should explicitly consider infrastructure, cost, and standardization requirements when selecting and implementing protocols.