The Nursing Interventions Classification (NIC) is one of the most comprehensive and widely utilized standardized nursing terminologies, offering a unified structure for describing, documenting, and evaluating nursing care. Over more than three decades of development, NIC has matured into an evidence-informed taxonomy that supports clinical decision-making across diverse specialties and care environments. The accelerating emphasis on digital health and evidence-based practice has further highlighted the value of structured intervention data for enhancing documentation quality, enabling interoperability, and facilitating informed clinical reasoning. Current research indicates that the systematic use of NIC contributes to improved accuracy in diagnostic reasoning, greater consistency in intervention selection, and more coherent linkage between patient assessments and outcomes. Within educational settings, the integration of NIC strengthens students’ analytical capabilities, fosters competency in informatics, and supports alignment with international standards for nursing education. Despite this progress, important challenges persist, including variations in implementation, limited outcome-focused research, and methodological heterogeneity across studies. This chapter synthesizes contemporary evidence on the development, integration, and effectiveness of NIC in clinical practice, education, and research, and discusses its growing significance in shaping a data-driven, technologically enhanced, and scientifically grounded nursing profession.