In the information age, where digital transformation is accelerating, the nursing discipline has become a strategic actor not only in the delivery of healthcare services but also in research, education, and policy-making. This book chapter explores the impact of multi-layered approaches such as evidence-based practices, big data analytics, digital health technologies, virtual simulation, gamification, and lifelong learning on nursing practice and education. Evidence-based decision-making processes not only enhance the quality of patient care but also support the provision of ethical, empathetic, and culturally sensitive services. The integration of digital tools into educational processes individualizes learning and fosters students' critical thinking, problem-solving abilities, and professional competencies. Digital competence frameworks and supportive programs offered by the European Union contribute to the structural reconstruction of nursing education by promoting digital inclusion. In conclusion, approaching research, practice, and education in nursing through a holistic perspective, rather than as isolated domains, will not only advance individual professional development but also enable sustainable improvements in the quality of healthcare services.